I've only just heard of this, and not tried it yet, but codon](https://github.com/exaloop/codon), a compiler that uses [LLVM to compile Python to native machine code, looks very interesting.
I've only just heard of this, and not tried it yet, but codon](https://github.com/exaloop/codon), a compiler that uses [LLVM to compile Python to native machine code, looks very interesting.